Doctoral student in Systems biology of liver diseases

School of Engineering Sciences in Chemistry, Biotechnology and Health at KTH

KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.

Project description

Third-cycle subject: Mardinoglu lab at SciLifeLab develop genome-scale metabolic models (GEMs) for human cells/tissues and employ these comprehensive models in the analysis of the omics data obtained from subjects with complex diseases including non-alcoholic fatty liver disease, type 2 diabetes and certain types of cancer (e.g. hepatocellular carcinoma). This is an exciting area of biomedical research, driven by the recent discoveries of metabolic reprogramming in common complex diseases.

The student will analyse genomics data obtained from patients with rare diseases, and identify potential pathogenic genetic alterations. The candidate will also integrate and interpret the genetic alteration in systems biology tools including regulatory, protein-protein interactions (PPIs) and co-expression networks. The aim is to use these biological networks in the analysis of the genomic data obtained from patients to identify potential drug targets and discover biomarker for the development of the efficient diagnostic and treatment strategies for rare diseases. More information can be found at http://sysmedicine.com

Supervision: The doctoral student will be supervised by Dr Adil Mardinoglu & Dr Cheng Zhang

What we offer

• The possibility to study in a dynamic and international research environment in collaboration with industries and prominent universities from all over the world Read more
• A workplace with many employee benefits and monthly salary according to KTH’s Doctoral student salary agreement
• A postgraduate education at an institution that is active and supportive in matters pertaining to working conditions, gender equality and diversity as well as study environment
• Help to relocate and be settled in Sweden and at KTH

Admission requirements

To be admitted to postgraduate education (Chapter 7, 39 § Swedish Higher Education Ordinance), the applicant must have basic eligibility in accordance with either of the following:

• passed a second cycle degree (for example a master’s degree),
• completed course requirements of at least 240 higher education credits, of which at least 60 second-cycle higher education credits, or
• acquired, in some other way within or outside the country, substantially equivalent knowledge
• master degree in Life Science, Systems Biology, Bioinformatics or equivalent relevant area
• strong background in both bioinformatics/systems biology, preferably experience in genomic analysis and eQTL identification
• fluency in written & spoken English

In addition to the above, there is also a mandatory requirement for English equivalent to English B/6, read more here

Selection

In order to succeed as a doctoral student at KTH you need to be goal oriented & persevering in your work. During the selection process, candidates will be assessed upon their ability to:

• independently pursue his or her work
• collaborate with others,
• have a professional approach
• analyse and work with complex issues
• passionate with scientific work

After the qualification requirements, great emphasis will be placed on personal competency.

Target degree:  Doctoral degree

Information regarding admission and employment

Only those admitted to postgraduate education may be employed as a doctoral student. The total length of employment may not be longer than what corresponds to full-time doctoral education in four years ‘ time. An employed doctoral student can, to a limited extent (maximum 20%), perform certain tasks within their role, e.g. training and administration. A new position as a doctoral student is for a maximum of one year, and then the employment may be renewed for a maximum of two years at a time.

Union representatives

You will find contact information for union representatives on KTH’s website

Doctoral section (Students’ union on KTH Royal Institute of Technology)

You will find contact information for doctoral section on the section’s website

Application

Apply for the position & admission through KTH’s recruitment system. It is the applicant’s responsibility to ensure that the application is complete in accordance with the instructions in the advertisement

Applications must be received at the last closing date at midnight, CET/CEST (Central European Time/Central European Summer Time)

Applications must include:

• CV including your relevant professional experience & knowledge
• Application letter with a brief description of why you want to pursue research studies, about what your academic interests are & how they relate to your previous studies & future goals (Max. 2 pages long)
• Copies of diplomas & grades from previous university studies & certificates of fulfilled language requirements (see above) Translations into English or Swedish if the original document is not issued in one of these languages
• Representative publications or technical reports. For longer documents, please provide a summary (abstract) & a web link to the full text

Other information

Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH & a given part of our values

For information about processing of personal data in the recruitment process please read here.

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